Teaching an old dog new tricks: potential antiatherothrombotic use for statins.

Teaching an old dog new tricks: drug repositioning in small cell lung cancer.

Jahchan and colleagues report the use of a biostatistical analysis to identify effective therapeutics for small cell lung cancer (SCLC). Their results reveal a new use for the tricyclic antidepressant imipramine in SCLC and shed light on the therapeutic potential of drug repositioning in cancer and other diseases.

Can old dogs learn new tricks?

Many of these old adages can’t be traced back to their origins, but the reference to senior dogs and their learning capacity has a documented origin. The source of these well-worn words is an English gentleman named Fitzherbert who wrote a treatise on animal husbandry in 1523. In the cumbersome vernacular of the times, he said that “the dogge must lerne when he is a whelpe, or els it wyl not be...

Colchicine in Acute Myocardial Infarction: “Teaching New Tricks to an Old Dog”

Drug development is often not as linear as one would think. Repurposing of drugs for new uses is now common [1]. This is certainly the case of colchicine. Colchicine is one of the oldest anti-inflammatory drugs [2]. Colchicine was historically used as an unapproved drug to treat Mediterranean fever. In 2009, following compelling evidence in vitro and in vitro of the ability of colchicine to inh...

Salicylic acid: an old dog, new tricks, and staphylococcal disease.

Aspirin has been shown to cause a reduction in the virulence of Staphylococcus aureus-associated endocarditis. A new study reveals that salicylic acid, the major metabolite of aspirin, acts at the level of transcription to downregulate the production of fibrinogen, fibronectin, and alpha-hemolysin - virulence factors necessary for bacterial replication in host tissues and, now, potential therap...

Teaching Old Dogs New Tricks Implementing Organizational Learning in an Asian National Police Force